An hour long episode on a weekly basis, I think. It's British, they've been accused of being very British apparently, they do sound quite intelligent and well spoken for game enthusiasts. There's news, reviews, features, guest spots, etc. all presented in a very irreverent manner. I recommend you give it a listen, it's ideal for the morning commute, if you have to tolerate such a thing.
You can download direct from the website or subscribe via RSS or iTunes.
I haven't listened to the latest one yet, only just heard the previous one. It had a great feature on The Lost Room, which I made another thread about, saying it was just like a videogame. Which is very true is true, what with the magic portal, collecting magical item and stuff.